AD7789
| Title: | AZD7789 (sabestomig) in relapsed / refractory classical Hodgkin Lymphoma |
| Info: | ClinTrial.gov |
| Type: | Classical Hodgkin Lymphoma |
| Centres: | Oxford |
| Description: | A phase I/II dose escalation and cohort expansion study if an anti-PD1 / anti-TIM3 bispecific antibody. |
STP938-101
| Title: | STP938 in relapsed / refractory B-cell and T-cell lymphoma |
| Info: | ClinTrial.gov |
| Type: | B-cell and T-cell lymphoma |
| Centres: | Oxford |
| Description: | A first in human, dose escalation study of the CTPD1 inhibitor STP938. |
SKYGLO
| Title: | Glofitamab in combination with Pola-R-CHP in 1st line large B-cell lymphoma |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | A phase III international, multicentre, open-label study comparing glofitamab in combination with Pola-R-CHP with R-CHOP in the front line treatment of large B-cell lymphoma |
SGN35-032
| Title: | Brentuximab vedotin with CHP in PTCL with CD30 expression of < 10% |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | An open label phase 2 study of BV combined with CHP in PTCL patient for first line treatment who have either no CD30 expression of 1-10% expression. |
P+R-ICE
| Title: | Pembrolizumab in combination with R-ICE chemotherapy in relapsed / refractory DLBCL |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | a randomised phase 2 study of pembrolizumab in combination with R-ICE chemotherapy in relapsed / refractory DLBCL |
PRIZM
| Title: | zanubrutinib monotherapy in relapsed or refractory primary CNS lymphoma |
| Info: | CancerResearch.uk |
| Centres: | Oxford |
| Description: | A phase II platform study of zanubrutinib monotherapy and combination therapy for relapsed and refractory CNS lymphoma |
CLL322 BRUIN
| Title: | CLL322 BRUIN |
| Info: | ClinTrial.gov |
| Type: | Relapsed CLL |
| Centres: | Oxford |
| Description: | A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma (CLL/ SLL) (BRUIN CLL-322) |
Mosunetuzumab and lenalidomide
| Title: | CO41942 |
| Info: | ClinTrial.gov |
| Type: | Relapsed Follicular Lymphoma |
| Centres: | Oxford |
| Description: | A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma |
MCL321 BRUIN
| Title: | MCL321 BRUIN |
| Info: | ClinTrial.gov |
| Type: | Relapsed MCL |
| Centres: | Oxford |
| Description: | Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321) |
NVG111
| Title: | NVG111 |
| Info: | ClinTrial.gov |
| Type: | Relapsed MCL, CLL |
| Centres: | Oxford |
| Description: | A phase I trial of NVG111, a ROR1 BiTE in relapsed CLL and mantle cell lymphoma. |
NX-5948-301
| Title: | NX-5948-301 |
| Info: | ClinTrial.gov |
| Type: | Relapsed/Refractory B-cell non-Hodgkin lymphoma and CLL |
| Centres: | Oxford |
| Description: | A phase 1 dose escalation trial of NX-5948, an oral BTK biodegrader of BTK. |
OASIS II
| Title: | OASIS II |
| Info: | ClinTrial.gov |
| Type: | Mantle cell lymphoma |
| Centres: | Oxford |
| Description: | A randomised trial of R-ibrutinib compared with R-ibrutinib-venetoclax in newly diagnosed mantle cell lymphoma stage 2 to stage 4. |
RADAR
| Title: | RADAR |
| Info: | ClinTrial.gov |
| Type: | Classical Hodgkin Lymphoma |
| Centres: | Oxford |
| Description: | A randomised trial comparing initial ABVD with AVD plus brentuximab vedotin in patients with previously untreated early stage classical Hodgkin Lymphoma (stage 1A or 2A, without bulk). An optional PET is performed after cycle 1. An interim PET after cycle 2 and for those PET negative, no radiotherapy will be given unless initial disease > 5cm or patient over 60y and decided in advance to offer radiotherapy. |
REMODL-A
| Title: | REMODL-A |
| Info: | ClinTrial.gov |
| Type: | Diffuse large B-cell lymphoma |
| Centres: | Oxford |
| Description: | A randomised trial of R-CHOP compared with R-CHOP (1:3) combined with acalabrutinib in newly diagnosed diffuse large B-cell lymphoma stage 1X to stage 4. |
PETRea
| Title: | PETRea |
| Info: | Cancer Research UK |
| Type: | Follicular Lymphoma |
| Centres: | Oxford |
| Description: | Randomised study in frontline treatment to determine the efficacy of maintenance rituximab in patients achieving CMR on end of induction PET scan. |
STELLAR
| Title: | STELLAR |
| Info: | ClinTrial.gov |
| Type: | Richters transformation of CLL |
| Centres: | Oxford |
| Description: | A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome (STELLAR) |
CARAMEL
| Title: | CARAMEL |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma (CARAMEL) |
Zilovertamab Vedotin
| Title: | MK-2140-006 |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) |
REFRACT
| Title: | Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy (REFRACT) |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy (REFRACT) |
CO43805
| Title: | CO43805 |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma |
BGB-11417
| Title: | BGB-11417 |
| Info: | ClinTrial.gov |
| Centres: | Oxford |
| Description: | Study of BGB-11417 Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma |
